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芬太尼誘導的咳嗽是術後噁心和嘔吐的危險因素


麻醉MGA背景與目的術後噁心嘔吐...

- 2018年10月09日23時53分
- 科學文摘 / 麻醉MedicalGroup

麻醉MedicalGroup

A comparison of postoperative emergence agitation between sevoflurane and thiopental anesthesia induction in pediatric patients

背景與目的

術後噁心嘔吐(PONV)和芬太尼誘導咳嗽(FIC)是兩種常見的麻醉相關併發症,且似乎有共同的危險因素。
在這項前瞻性隊列研究中,我們調查了麻醉誘導期間有FIC的患者是否會出現PONV發病率增加。


方 法

我們研究了2011年7月1日至2012年7月30日期間入組的成人非吸菸婦科手術患者。記錄誘導期間FIC的術後PONV的發生。
對芬太尼誘導的咳嗽和其他圍手術期變量進行多變量分析,以確定FIC和PONV之間的關係。

結 果

所有參加本研究的502名患者至少有兩個PONV危險因素,154名(31%)患者發生FIC。
FIC組的PONV發生率高於非FIC組(56.5 vs 38.2%; P <0.0001)。
多變量邏輯回歸分析發現FIC是發生PONV的預測性危險因素(校正比值比2.08,95%置信區間1.41-3.07)。

結 論


不吸菸婦女接受婦科手術,在麻醉誘導期間發生FIC,術後PONV的發生率也較高。

原始文獻摘要

Son J S, Jang E, Oh M W, et al. A comparison of postoperative emergence agitation between sevoflurane and thiopental anesthesia induction in pediatric patients. Korean J Anesthesiol, 2018,

68(4):373-378.

Background: Postoperative nausea and vomiting (PONV) and fentanyl-induced cough (FIC) are two common anaesthesia-related events, which seem to have common risk factors. In this

prospective cohort study, we investigatewhether patients who have FIC during induction of anaesthesia have an increased incidence of PONV.

Methods: We studied adult non-smoking gynaecological surgical patients enrolled between July 1, 2011 and July 30, 2012. The

presence of FIC during induction and the occurrence of PONV were recorded. Fentanyl-induced cough and other perioperative variables were subjected to multivariate analysis to determine the


association between FIC and PONV.

Results: All 502 patients enrolled in this study had at least two risk factors for PONV, and 154 (31%) developed FIC. The incidence of PONV in the FIC group was higher than in the

non-FIC group (56.5 vs 38.2%; P<0.0001). Multivariate logistic regression analysis found FIC to be a predictive risk factor for the development of PONV (adjusted odds ratio 2.08, 95% confidence

interval 1.41–3.07).

Conclusions: Non-smoking women undergoing gynaecological surgery who develop FIC during induction of anaesthesia have a higher incidence of PONV.

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